Cytotoxic and Insecticidal Activities of Derivatives of Harmine, a Natural Insecticidal Component Isolated from Peganum harmala
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چکیده
منابع مشابه
Cytotoxic and insecticidal activities of derivatives of harmine, a natural insecticidal component isolated from Peganum harmala.
In a continuing effort to develop novel β-carbolines endowed with better insecticidal activity, a simple high-yielding method for the synthesis of harmine compounds starting from L-tryptophan has been developed and a series of 1,3-substituted β-carboline derivatives have been synthesized and evaluated for their cytotoxicity against insect cultured Sf9 cell line in vitro and insecticidal activit...
متن کاملVasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta.
The present work describes the mechanisms involved in the vasorelaxant effect of harmine and harmaline. These alkaloids induce in a dose-dependent manner the relaxation in the aorta precontracted with noradrenaline or KCl. However, the removal of endothelium or pre-treatment of intact aortic ring with L-NAME (inhibitor of NOSe synthetase) or with indomethacin (non-specific inhibitor of cyclo-ox...
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Plants are the natural factories for the synthesis of variety of bioactive compounds. This diverse chemical setup of the plants speaks their important role as biomedicine. These biomolecules are often toxic to both plants and animals. The methanolic extract of Calendula arvensis was screened for its toxic potential against Lemna minor, Artimia salina (Brine shrimps) larvae and some important gr...
متن کاملInsecticidal and Nematicidal Activities of Novel Mimosine Derivatives.
Mimosine, a non-protein amino acid, is found in several tropical and subtropical plants, which has high value for medicine and agricultural chemicals. Here, in continuation of works aimed to development of natural product-based pesticidal agents, we present the first significant findings for insecticidal and nematicidal activities of novel mimosine derivatives. Interestingly, mimosinol and deut...
متن کاملCytotoxicity of alkaloids isolated from Peganum harmala seeds.
ETHNOPHARMACOLOGICAL RELEVANCE Peganum harmala is used in traditional medicine to treat a number of diseases including cancer. Our preliminary studies show that the alkaloidal extract of PH seed is cytotoxic to several tumor cell lines in vitro and has antitumor effect in a tumor model in vivo. The present investigation was aimed at extending our previous studies in identifying the components i...
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ژورنال
عنوان ژورنال: Molecules
سال: 2010
ISSN: 1420-3049
DOI: 10.3390/molecules15117775